LYSOSOMAL ACID LIPASE A MODULATES LEUKEMIA STEM CELL RESPONSE TO VENETOCLAX/TYROSINE KINASE INHIBITOR COMBINATION THERAPY IN BLAST PHASE CHRONIC MYELOID LEUKEMIA

The treatment of blast phase chronic myeloid leukemia (bpCML) remains a challenge due at least in part to drug resistance of leukemia stem cells (LSCs).Recent clinical evidence suggests that the BCL-2 inhibitor venetoclax in combination with ABL-targeting tyrosine kinase Floor Spray Mop inhibitors (TKIs) can eradicate bpCML LSCs.In this report, we

A hybrid alternate current/direct current (AC/DC) microgrid consists of an AC subgrid and a DC subgrid, and the subgrids are connected through the interlink bidirectional AC/DC converter.In the stand-alone operation mode, it is desirable that the interlink bidirectional AC/DC converter manages proportional power sharing between the subgrids by tran

Abstract Background Current approaches to identifying drug-drug interactions (DDIs), include safety studies during drug development and post-marketing surveillance after approval, offer important opportunities to identify potential safety issues, but are unable to provide complete set of all possible DDIs.Thus, the drug discovery researchers and he

Access to education and training has been a growing concern to different international organizations, and the concern for socially vulnerable pycnogenol groups at risk of exclusion, such as the prison population, in particular, has been increasingly evident.In this context, and assuming that education and training in prisons must have a similar deg

Background: Soft tissue sarcomas (STS) are heterogeneous tumors derived from mesenchymal cells that differentiate into soft tissues.The prognosis of patients who present with an STS is influenced by the regulation of a complex gene network.Methods: Weighted gene co-expression network analysis (WGCNA) was performed to identify gene modules associate